That laid the groundwork for allowing DNA repair to occur in space, providing the opportunity to gain insight into the type of repair mechanism used. Scientists harnessed this naturally occurring immune response to create the technique.īy using CRISPR, the researchers can create precisely controlled breaks in a known location of the genome, eliminating possible risks from random damage. Bacteria transcribe the viral DNA sequences to RNA, which then guides a specific protein to the viral DNA and cuts it. These are short, repeated sequences of DNA in bacteria with viral DNA sequences in between them. To generate DNA breaks at specific locations, the team used a genome editing technique called CRISPR, which stands for Clustered Regularly Interspaced Short Palindromic Repeats. The team also are co-authors on the results paper. They earned the opportunity to participate in this research as a part of the Genes in Space program, a national contest that challenges students in grades seven through 12 to design DNA analysis experiments using the ISS US National Lab and tools aboard the station. Genes in Space-6 was the brainchild of four students from Minnesota: Aarthi Vijayakumar, Michelle Sung, Rebecca Li, and David Li. Technical and safety concerns had prevented study of these repair processes aboard the space station until now. The other method rejoins the strands without changing the DNA sequence. In one method, bases may be added or deleted. The body repairs double-strand breaks in DNA-the severing of both of the intertwined strands of the double helix-one of two major ways. These results significantly expand the space station’s molecular biology toolkit, enabling studies of DNA repair and a variety of other biological investigations in microgravity. ![]() ![]() By subscribing, you agree to receive email related to Lab Manager content and products.
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